Studies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys
نویسندگان
چکیده
Acute disseminated encephalomyelitis has been produced in rhesus monkeys by injection of their own brain tissue, removed surgically and incorporated with adjuvants.
منابع مشابه
Rapid production of acute disseminated encephalomyelitis in rhesus monkeys by injection of brain tissue with adjuvants.
Rapid production in the monkey of a pathological condition resembling acute disseminated encephalomyelitis, marked by demyelination, can be achieved by the use of adjuvants added to rabbit brain emulsions.
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1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and hist...
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Multiple lesions of the central nervous system characterized by their wide dissemination, predilection for the white matter, perivascular position, inflammation, proliferation of histiocytes, giant cell formation, and associated demyelination, have been produced in several laboratories by intramuscular injection into monkeys of emulsions and extracts of rabbit brain (1-3). The procedure, howeve...
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No evidence was found to support the idea that vaccine virus placed in the cisterna magna is capable of producing an acute disseminated encephalomyelitis with perivascular demyelination either in normal or in partially immune monkeys. A testicular extract (Reynals' factor) did not induce vaccine virus to cause an acute disseminated encephalomyelitis in monkeys. Repeated intramuscular injections...
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The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intr...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 92 شماره
صفحات -
تاریخ انتشار 1948